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Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.

PBB Protein STK10 image.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Aliases STK10, LOK, PRO2729, serine/threonine kinase 10
External IDs MGI: 1099439 HomoloGene: 38122 GeneCards: STK10
Targeted by Drug
RNA expression pattern
PBB GE STK10 203047 at tn.png

PBB GE STK10 40420 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 172.04 – 172.19 Mb Chr 11: 32.53 – 32.62 Mb
PubMed search
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.

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