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SPEG complex locus, also known as SPEG, is a human gene.

SPEG
Protein SPEG PDB 1u2h.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SPEG, APEG-1, APEG1, BPEG, SPEGalpha, SPEGbeta, CNM5, SPEG complex locus
External IDs MGI: 109282 HomoloGene: 55619 GeneCards: SPEG
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001173476
NM_005876

NM_001085370
NM_001085371
NM_001173477
NM_007463

RefSeq (protein)

NP_001166947.1
NP_005867.3

NP_001078839.1
NP_001078840.1
NP_001166948.1

Location (UCSC) Chr 2: 219.43 – 219.5 Mb Chr 1: 75.38 – 75.43 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

SPEG complex locus, also known as SPEG, is a human gene.

Expression of this gene is thought to serve as a marker for differentiated vascular smooth muscle cells which may have a role in regulating growth and differentiation of this cell type. The encoded protein is highly similar to the corresponding rat and mouse proteins. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of only one variant has been defined.

Mouse Mutant Alleles for Speg
Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI Speg
Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse. Speg
Example structure of targeted conditional mutant allele for this gene
Molecular structure of Speg region with inserted mutation sequence
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Speg:

see Knockout mouse