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Mitochondrially encoded NADH dehydrogenase 2 is protein that in humans is encoded by the mitochondrial gene MT-ND2 gene. The ND2 protein is a subunit of NADH dehydrogenase , which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variants of MT-ND2 are associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes , Leigh's syndrome , Leber's hereditary optic neuropathy and increases in adult BMI.

ND2
Identifiers
Aliases ND2, complex I ND2 subunit, NAD2, NADH-ubiquinone oxidoreductase chain 2, MT-MTND2
External IDs MGI: 102500 HomoloGene: 5019 GeneCards: ND2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

NP_904329.1

Location (UCSC) Chr M: 0 – 0.01 Mb n/a
PubMed search
Wikidata
View/Edit Human View/Edit Mouse
Location of the MT-ND2 gene in the human mitochondrial genome. MT-ND2 is one of the seven NADH dehydrogenase mitochondrial genes (yellow boxes).

Mitochondrially encoded NADH dehydrogenase 2 is protein that in humans is encoded by the mitochondrial gene MT-ND2 gene. The ND2 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variants of MT-ND2 are associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), Leigh's syndrome (LS), Leber's hereditary optic neuropathy (LHON) and increases in adult BMI.

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