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NADH-ubiquinone oxidoreductase chain 1 is a protein that in humans is encoded by the mitochondrial gene MT-ND1. The ND1 protein is a subunit of NADH dehydrogenase, which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variants of the MT-ND1 gene are associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes , Leigh's syndrome , Leber's hereditary optic neuropathy and increases in adult BMI.

ND1
Identifiers
Aliases ND1, MTMT-NADH dehydrogenase, subunit 1 (complex I)
External IDs MGI: 101787 HomoloGene: 5011 GeneCards: ND1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

NP_904328.1

Location (UCSC) Chr M: 0 – 0 Mb n/a
PubMed search
Wikidata
View/Edit Human View/Edit Mouse
Location of the MT-ND1 gene in the human mitochondrial genome. MT-ND1 is one of the seven NADH dehydrogenase mitochondrial genes (yellow boxes).

NADH-ubiquinone oxidoreductase chain 1 is a protein that in humans is encoded by the mitochondrial gene MT-ND1. The ND1 protein is a subunit of NADH dehydrogenase, which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variants of the MT-ND1 gene are associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), Leigh's syndrome (LS), Leber's hereditary optic neuropathy (LHON) and increases in adult BMI.

ND1

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