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Kynureninase or L-Kynurenine hydrolase is a PLP dependent enzyme that catalyses the cleavage of kynurenine into anthranilic acid . It can also act on 3hKyn and some other -alanines. Humans express one kynureninase enzyme that is encoded by the KYNU gene located on chromosome 2.

kynureninase
Kynureninase2HZP.jpg
Crystal structure of Homo sapiens kynureninase.
Identifiers
EC number 3.7.1.3
CAS number 9024-78-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
Gene Ontology
KYNU
PDB 3e9k EBI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KYNU, KYNUU, kynureninase
External IDs OMIM: 605197 MGI: 1918039 HomoloGene: 2925 GeneCards: KYNU
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001032998
NM_001199241
NM_003937

NM_027552
NM_001289593
NM_001289594

RefSeq (protein)

NP_001028170.1
NP_001186170.1
NP_003928.1

NP_001276522.1
NP_001276523.1
NP_081828.1

Location (UCSC) Chr 2: 142.88 – 143.06 Mb Chr 2: 43.56 – 43.68 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Kynureninase or L-Kynurenine hydrolase (KYNU) (EC 3.7.1.3) is a PLP dependent enzyme that catalyses the cleavage of kynurenine (Kyn) into anthranilic acid (Ant). It can also act on 3hKyn (to produce 3hAnt) and some other (3-arylcarbonyl)-alanines. Humans express one kynureninase enzyme that is encoded by the KYNU gene located on chromosome 2.

KYNU is part of the pathway for the catabolism of Trp and the biosynthesis of NAD cofactors from tryptophan (Trp).

Kynureninase catalyzes the following reaction:

What does kynureninase mean?

What does kynureninase mean? A spoken definition of kynureninase. Intro Sound: Typewriter - Tamskp Licensed under CC:BA 3.0 Outro Music: Groove Groove ...

Gene Music using Protein Sequence of KYNU "KYNURENINASE"

Gene Music using Protein Sequence of KYNU "KYNURENINASE"

How to Pronounce Kynureninase

This video shows you how to pronounce Kynureninase.

Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated

Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback.

Kynurenine | Wikipedia audio article

This is an audio version of the Wikipedia Article: Kynurenine Listening is a more natural way of learning, when compared to reading. Written language only ...

Kynurenine | Wikipedia audio article

This is an audio version of the Wikipedia Article: Kynurenine 00:01:16 undefined 00:02:42 undefined Listening is a more natural way of learning, when ...