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Inositol trisphosphate receptor is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositol trisphosphate . InsP3R is very diverse among organisms, and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory. Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca2+ from intracellular store sites. There is strong evidence suggesting that the InsP3R plays an important role in the conversion of external stimuli to intracellular Ca2+ signals characterized by complex patterns relative to both space and time. For example, Ca2+ waves and oscillations. The InsP3 receptor was first purified from rat cerebellum by neuroscientists Surachai Supattapone and Solomon Snyder at Johns Hopkins University School of Medicine.

inositol 1,4,5-trisphosphate receptor, type 1
1XZZ.pdb.jpg
Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor
Identifiers
Symbol ITPR1
Entrez 3708
HUGO 6180
OMIM 147265
RefSeq NM_002222
UniProt Q14643
Other data
Locus Chr. 3 p26.1
inositol 1,4,5-trisphosphate receptor, type 2
Identifiers
Symbol ITPR2
Entrez 3709
HUGO structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor 6181 Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor 6181
OMIM 600144
RefSeq NM_002223
UniProt Q14571
Other data
Locus Chr. 12 p11.23
inositol 1,4,5-trisphosphate receptor, type 3
Identifiers
Symbol ITPR3
Entrez 3710
HUGO 6182
OMIM 147267
RefSeq NM_002224
UniProt Q14573
Other data
Locus Chr. 6 p21.31

Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca channel activated by inositol trisphosphate (InsP3). InsP3R is very diverse among organisms, and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory. Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca from intracellular store sites. There is strong evidence suggesting that the InsP3R plays an important role in the conversion of external stimuli to intracellular Ca signals characterized by complex patterns relative to both space and time. For example, Ca waves and oscillations. The InsP3 receptor was first purified from rat cerebellum by neuroscientists Surachai Supattapone and Solomon Snyder at Johns Hopkins University School of Medicine.