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IISER Pune uses nanovesicles to improve cancer drug delivery - The Hindu

Since producing inhibitors against RalA protein is challenging and the existing inhibitor is not specific (targets both RalA and RalB), the researchers chose to target Aurora Kinase A (AURKA) instead. Aberrant AURKA activity has been implicated in ...

Next-Gen Antisense and Small Molecule Protein-Protein Disruptors Benefit SOD1 Models - ALS Research Forum

Though mutations in superoxide dismutase 1 (SOD1) have been a known cause of familial ALS for more than two decades, researchers have had little success suppressing the mutant protein in patients. While initial antisense oligonucleotides (ASOs) proved ...

Novel Protein Inhibitors Could Enhance Immunotherapy Response in Patients with Cancer - Drug Discovery & Development

Immunotherapy has shown great promise in cancer care but reports of relatively low overall patient response rates are spurring the search for ways to enhance its efficacy. One of the most intriguing avenues of research involves combination treatments ...

Global Protein Kinase Inhibitor Market 2017 Segmentation, Demand, Growth, Trend, Opportunity and Forecast to 2022 - Latest Industry News (press release) (blog)

The report delves into the Global Protein Kinase Inhibitor market to gauge its current and future potential. It leverages historical statistics about the Protein Kinase Inhibitor market, data from various other paid websites and sources, and inputs by ...

VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma - Science Magazine

They identified ZHX2, a protein with structural motifs that indicate DNA binding. ZHX2 has been implicated in tumor suppression. Loss of ZHX2 inhibited signaling through the transcription factor NF-κB, and ZHX2 bound to many NF-κB target genes ...

Critical Role of PRMT5 Protein Uncovered in the Production of Myelin - Genetic Engineering & Biotechnology News

In the second cohort, they used a pharmacological inhibitor to block the activity of the protein. In the final cohort, they studied a group of knock-out mice who were born without the PRMT5-producing gene. In each case, removing or blocking PRMT5 ...

Study uncovers new protein complex that shields broken DNA ends - News-Medical.net

When intact, the newly discovered Shieldin complex was found to contribute to this vulnerability by attaching to the broken DNA, forcing cancer cells to attempt to repair their DNA in a way that makes them susceptible to PARP inhibitors and platinum ...

p70S6 Kinase (p70S6K or 70-kDa Ribosomal Protein S6 Kinase) Inhibitor Market Professional and In-Depth Industry ... - Healthcare Sector

The Research Report of p70S6 Kinase (p70S6K or 70-kDa Ribosomal Protein S6 Kinase) Inhibitor Market 2018 point of convergence on top to bottom p70S6 Kinase (p70S6K or 70-kDa Ribosomal Protein S6 Kinase) Inhibitor Market analysis and future ...

Scientists uncover DNA 'shield' withcrucial roles in normal cell division - EurekAlert (press release)

Scientists have made a major discovery about how cells repair broken strands of DNA that could have huge implications for the treatment of cancer. Their study, published in Nature today (Wednesday), uncovered a brand new protein complex in cells that ...

Tackling Cancer at Ground Zero With Designer Molecules - R & D Magazine

The DNA slides through the centre of this donut-shaped protein where it is replicated. "If we can inhibit the action of this protein, the cells can't make DNA, so they can't divide. This is really tackling cancer at ground zero. It's stopping cell ...

Tackling Cancer at Ground Zero: Designer Molecule Inhibits Protein Target - Technology Networks

That means it is a potential target for inhibiting the growth of multiple cancers, not just a select few. "And importantly, this protein seldom mutates which means that it is less likely to develop resistance against a drug inhibitor." The research, in ...

Unique BIR domain sets determine inhibitor of apoptosis protein–driven cell death and NOD2 complex signal specificity - Science

Inhibitor of apoptosis proteins (IAPs) are involved in regulating cell death and inflammation. As such, both gain and loss of IAP function are associated with various diseases, from cancer to immune disorders. Chirieleison et al. examined the ...

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia - Science

Consequently, coexpression of TNK2 and mutant PTPN11 synergistically increased mitogen-activated protein kinase (MAPK) signaling and enhanced colony formation in bone marrow cells from mice. Chemical inhibition of TNK2 blocked MAPK signaling and ...

The Major Tegument Protein of Bovine Herpesvirus 1, VP8, Interacts with DNA Damage Response Proteins and ... - Journal of Virology

We demonstrated that VP8 interacts with DNA damage response proteins and disrupts the ATM-NBS1-SMC1 pathway by inhibiting phosphorylation of DNA repair proteins NBS1 and SMC1. Furthermore, interference of VP8 with DNA repair was correlated ...

Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L - Journal of Virology

Studies on the antiviral mechanisms of ISG15 have demonstrated that ISGylation regulates various steps of the virus life cycle. ISGylation can directly inhibit the functions of viral proteins. ISGylation of the influenza A virus (IAV) NS1 protein ...

Protein Phosphatase 1α Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral ... - Journal of Virology

The significance of our research is in identifying the interaction between protein phosphatase 1 (PP1) and the viral capsid protein. This interaction is important for viral replication, as inhibition of PP1 results in decrease viral replication ...

Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the ... - Journal of Virology

Overexpression of either RIG-I or MDA5 resulted in a significant activation of IFN-β promoter, and this activation did not appear to be inhibited by NS6 protein. These results are consistent with those shown in Fig. 1A and 3A and B. RIG-I/MDA5-mediated ...

Cancer's Grip May Be Loosened by Tampering with DNA Clamp - Genetic Engineering & Biotechnology News

The scientists, led by John Bruning, Ph.D., structural biologist at the University of Adelaide, say that their drug-like protein is unlikely to provoke resistance because PCNA seldom mutates. The scientists add that inhibiting PCNA, which is also known ...

China's Ascentage Pharma Snags $150 Million to Support Pipeline Development - BioSpace (press release) (blog)

Ascentage is developing therapeutics that inhibit protein-protein interactions in order to restore apoptosis, or programmed cell death, in cancers, the company said. The company has a pipeline of seven clinical candidates, including a novel, highly ...

Resverlogix Announces Upcoming Presentations at Clinical Trials in Alzheimer's Disease (CTAD) Asia and Alzheimer's ... - GlobeNewswire (press release)

In addition, Dr. Cummings will present a poster titled, “Effect of the BET Protein Inhibitor Apabetalone on Serum Markers of Potential Importance for Cognitive Decline in Cardiovascular Disease Patients,” illustrating new data from the proteomic ...

The inhibitor protein is situated in the mitochondrial matrix and protects the cell against rapid ATP hydrolysis during momentary ischaemia. In oxygen absence, the pH of the matrix drops. This causes IP to become protonated and change its conformation to one that can bind to the F1Fo synthetase and stops it thereby preventing it from moving in a backwards direction and hydrolyze ATP instead of make it. When oxygen is finally incorporated into the system, the pH rises and IP is deprotonated. IP dissociates from the F1Fo synthetase and allows it to resume its ATP synthesis.

The inhibitor protein (IP) is situated in the mitochondrial matrix and protects the cell against rapid ATP hydrolysis during momentary ischaemia. In oxygen absence, the pH of the matrix drops. This causes IP to become protonated and change its conformation to one that can bind to the F1Fo synthetase and stops it thereby preventing it from moving in a backwards direction and hydrolyze ATP instead of make it. When oxygen is finally incorporated into the system, the pH rises and IP is deprotonated. IP dissociates from the F1Fo synthetase and allows it to resume its ATP synthesis.

50s ribosome inhibitor mode of action

This antibiotic video tutorial explains the mode of action of 50s ribosome inhibitor antibiotics. These antibiotics are among protein biosynthesis inhibitors.

Intro to Bacteria & Antibiotics: Protein Synthesis Inhibitors Pt. I

5. Protein Synthesis Inhibitors Pt. I This video is part of a comprehensive medical school microbiology, immunology & infectious diseases course.

Pharmacology – ANTIBIOTICS – NUCLEIC ACID & FOLIC ACID & PROTEIN SYNTHESIS INHIBITORS (MADE EASY)

Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed ...

19 protein synthesis inhibitor

DRUG-LIKE INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS: PEPTIDE MIMICRY AND FRAGMENT APPROACHES

David Fry at Boulder Peptide Symposium 2012, Head Biostructures Group, Roche Research Center, Nutley, NJ.

Protein synthesis inhibitors - Tetracyclines, Macrolides, Clindamycin

via YouTube Capture.