The enzyme cytochrome c oxidase or Complex IV, EC 18.104.22.168 is a large transmembrane protein complex found in bacteria and the mitochondrion of eukaryotes.
|Cytochrome c oxidase|
The crystal structure of bovine cytochrome c oxidase in a phospholipid bilayer. The intermembrane space lies to top of the image. Adapted from (It is a homo dimer in this structure)
It is the last enzyme in the respiratory electron transport chain of mitochondria (or bacteria) located in the mitochondrial (or bacterial) membrane. It receives an electron from each of four cytochrome c molecules, and transfers them to one oxygen molecule, converting molecular oxygen to two molecules of water. In the process, it binds four protons from the inner aqueous phase to make water, and in addition translocates four protons across the membrane, helping to establish a transmembrane difference of proton electrochemical potential that the ATP synthase then uses to synthesize ATP.
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what is cytochrome , different type of cytochromes , structure , active sites and functions.