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Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. P450scc is a mitochondrial enzyme that catalyzes conversion of cholesterol to pregnenolone. This is the first reaction in the process of steroidogenesis in all mammalian tissues that specialize in the production of various steroid hormones.

CYP11A1
3n9y.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CYP11A1, CYP11A, CYPXIA1, P450SCC, cytochrome P450 family 11 subfamily A member 1
External IDs OMIM: 118485 MGI: 88582 HomoloGene: 37347 GeneCards: CYP11A1
Targeted by Drug
mitotane
RNA expression pattern
PBB GE CYP11A1 204309 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099773
NM_000781

NM_019779

RefSeq (protein)

NP_000772.2
NP_001093243.1

NP_062753.3

Location (UCSC) Chr 15: 74.34 – 74.37 Mb Chr 9: 58.01 – 58.03 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. P450scc is a mitochondrial enzyme that catalyzes conversion of cholesterol to pregnenolone. This is the first reaction in the process of steroidogenesis in all mammalian tissues that specialize in the production of various steroid hormones.

cholesterol + 3 NADPH + 3 H + 3 O2 ⇄ pregnenolone + 4-methylpentanal + 3 NADP + 3 H2O

P450scc is a member of the cytochrome P450 superfamily of enzymes (family 11, subfamily A, polypeptide 1). The gene name is CYP11A1.