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The Supreme Tribunal of the Apostolic Signatura is the highest judicial authority in the Catholic Church . In addition, it oversees the administration of justice in the Church.

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The Supreme Tribunal of the Apostolic Signatura (Latin: Supremum Tribunal Signaturae Apostolicae) is the highest judicial authority in the Catholic Church (apart from the Pope himself, who as supreme ecclesiastical judge is the final point of appeal for any ecclesiastical judgment). In addition, it oversees the administration of justice in the Church.

The Prefect of the Supreme Tribunal of the Apostolic Signatura (since 8 November 2014) is Cardinal Dominique Mamberti, who had replaced Cardinal Raymond Leo Burke. The Secretary (since 16 July 2016) is Bishop Giuseppe Sciacca, who replaced Archbishop Frans Daneels, O. Praem.

The Supreme Tribunal of the Apostolic Signatura is housed in the Italian Renaissance-era Palazzo della Cancelleria in Rome, Italy, which also is the headquarters and meeting place of the Roman Catholic Church's other two Tribunals. The Apostolic Signatura only hears appeals from these two tribunals (which normally have final and universal [worldwide Church] appellate jurisdiction over their respective areas of competence) if some process was in error or there is an inter-agency conflict, and usually not in regard to the judgment which was made or the merits of the case. The two other Tribunals located there are the Sacred Roman Rota (which is normally the final appellate tribunal of the Church for most court cases, especially regarding marriage nullity, decisions of Bishops, and ecclesiastical trials and disciplinary procedures), and the Apostolic Penitentiary (which is normally the Church's final appellate tribunal regarding all matters having to do with the forgiveness of sins and the proper celebration of the Sacrament of Reconciliation).

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