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Aldosterone synthase is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone. It is a protein which is only expressed in the zona glomerulosa of the adrenal cortex and is primarily regulated by the renin-angiotensin system. It is the sole enzyme capable of synthesizing aldosterone in humans and plays an important role in electrolyte balance and blood pressure.

CYP11B2
Aldosteronecomplexdeoxycorticosterone.jpg
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases CYP11B2, ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo, cytochrome P450 family 11 subfamily B member 2
External IDs MGI: 88583 HomoloGene: 106948 GeneCards: CYP11B2
EC number 1.14.15.4
Targeted by Drug
fadrozole
RNA expression pattern
PBB GE CYP11B2 214630 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000498

NM_001033229

RefSeq (protein)

NP_000489.3

n/a

Location (UCSC) Chr 8: 142.91 – 142.92 Mb Chr 15: 74.83 – 74.84 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Aldosterone synthase is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone. It is a protein which is only expressed in the zona glomerulosa of the adrenal cortex and is primarily regulated by the renin-angiotensin system. It is the sole enzyme capable of synthesizing aldosterone in humans and plays an important role in electrolyte balance and blood pressure.